Protein Details: Aquaporin Z
Protein ID
ICDB_Pro_1238
Protein Name
Aquaporin Z
Gene Name
aqpZ; SO_1307
Organism
Shewanella oneidensis (strain ATCC 700550 / JCM 31522 / CIP 106686 / LMG 19005 / NCIMB 14063 / MR-1)
Length
231 amino acids
AlphaFoldDB
AF-Q8EHC1-F1-model_v4.pdb
Function
Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity.
Sequence
MNMSQKMAAEFLGTLWLVLGGCGSAVLAAAFPEVGIGLLGVSLAFGLTVLTMAFAIGHISGCHLNPAVSFGLWAGGRFPTSELLPYIIAQVAGGIAGAGVLYLIASGQEGFSLAAGFASNGFGEHSPGGYSMISVMICEIVMTLFFLLVILGSTDERAPKGFAPIAIGLCLTLIHLISIPISNTSVNPARSTGPALFVGDWAVSQLWLFWAAPIIGAILAGVIYRYFNAAK
PDB Structures
Ligand Binding
Binding Site
SITE 22: "Involved in tetramerization or stability of the tetramer"; SITE 45: "Selectivity filter"; SITE 175: "Selectivity filter"; SITE 184: "Selectivity filter"; SITE 190: "Selectivity filter"
Disease
Location
DOI ID
10.1038/nbt749
RefSeq
NP_716927.2; WP_011071520.1